› 5qrl

X-ray diffraction
1.76Å resolution

PanDDA analysis group deposition -- Crystal Structure of human Brachyury in complex with Z437516460

Released:
DOI: 10.2210/pdb5qrl/pdb
PDB 5qrl coloured by chain and viewed from the front.
PDB 5qrl coloured by chain and viewed from the side.
PDB 5qrl coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Newman JA, Gavard AE, Fernandez-Cid A, Sherestha L, Burgess-Brown NA, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Gileadi O

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-box transcription factor T Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 19.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15178 (Residues: 41-211; Coverage: 39%)
Gene names: T, TBXT
Sequence domains: T-box

Ligands and Environments

2 bound ligands:
Ligand CD 5 x CD
Ligand NWY 1 x NWY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P4122
Unit cell:
a: 60.104Å b: 60.104Å c: 110.242Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.22 0.261
Expression system: Escherichia coli

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