› 5qr8

X-ray diffraction
1.85Å resolution

PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z57258487

Released:
DOI: 10.2210/pdb5qr8/pdb
PDB 5qr8 coloured by chain and viewed from the front.
PDB 5qr8 coloured by chain and viewed from the side.
PDB 5qr8 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Bezerra GA, Foster W, Bailey H, Shrestha L, Krojer T, Talon R, Brandao-Neto J, Douangamath A, Nicola BB, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Brennan PE, Yue WW

Function and Biology Details

Reaction catalysed: 
Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5-aminolevulinate synthase, erythroid-specific, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 469 amino acids
Theoretical weight: 52.25 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P22557 (Residues: 143-578; Coverage: 74%)
Gene names: ALAS2, ALASE, ASB
Sequence domains: Aminotransferase class I and II

Ligands and Environments


Cofactor: Ligand PLP 2 x PLP
1 bound ligand:
Ligand NVD 1 x NVD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 125.33Å b: 108.28Å c: 75.64Å
α: 90° β: 109.11° γ: 90°
R-values:
R R work R free
0.21 0.209 0.241
Expression system: Spodoptera frugiperda

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