X-ray diffraction
1.71Å resolution

PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z915492990

Source organism: Homo sapiens
Entry authors: Bezerra GA, Foster W, Bailey H, Shrestha L, Krojer T, Talon R, Brandao-Neto J, Douangamath A, Nicola BB, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Brennan PE, Yue WW

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
5-aminolevulinate synthase, erythroid-specific, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 469 amino acids
Theoretical weight: 52.25 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P22557 (Residues: 143-578; Coverage: 74%)
Gene names: ALAS2, ALASE, ASB
Sequence domains: Aminotransferase class I and II

Ligands and Environments

Cofactor: Ligand PLP 2 x PLP
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 126.695Å b: 108.659Å c: 75.934Å
α: 90° β: 109.13° γ: 90°
R R work R free
0.212 0.21 0.239
Expression system: Spodoptera frugiperda