X-ray diffraction
1.49Å resolution

PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z2856434899

Source organism: Homo sapiens
Entry authors: Bezerra GA, Foster W, Bailey H, Shrestha L, Krojer T, Talon R, Brandao-Neto J, Douangamath A, Nicola BB, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Brennan PE, Yue WW

Function and Biology Details

Reaction catalysed:
Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
5-aminolevulinate synthase, erythroid-specific, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 469 amino acids
Theoretical weight: 52.25 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P22557 (Residues: 143-578; Coverage: 74%)
Gene names: ALAS2, ALASE, ASB
Sequence domains: Aminotransferase class I and II

Ligands and Environments

Cofactor: Ligand PLP 2 x PLP
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 125.696Å b: 108.463Å c: 75.697Å
α: 90° β: 108.98° γ: 90°
R R work R free
0.21 0.209 0.232
Expression system: Spodoptera frugiperda