X-ray diffraction
1.9Å resolution

PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with Z2895259681

Source organism: Homo sapiens
Entry authors: Nelson ER, Velupillai S, Talon R, Collins PM, Krojer T, Wang D, Brandao-Neto J, Douangamath A, Burgess-Brown N, Arrowsmith CH, Bountra C, Huber K, von Delft F

Function and Biology Details

Reaction catalysed:
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] + H(2)O = N(7)-methylguanosine 5'-diphosphate + 5'-phospho-[mRNA]
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
m7GpppN-mRNA hydrolase Chain: A
Molecule details ›
Chain: A
Length: 167 amino acids
Theoretical weight: 19.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8IU60 (Residues: 95-260; Coverage: 40%)
Gene names: DCP2, NUDT20
Sequence domains: NUDIX domain
Structure domains: Nucleoside Triphosphate Pyrophosphohydrolase

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 47.804Å b: 61.041Å c: 65.76Å
α: 90° β: 90° γ: 90°
R R work R free
0.204 0.202 0.253
Expression system: Escherichia coli