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Covalent fragment group deposition -- Crystal Structure of OUTB2 in complex with PCM-0102954

Source organism: Homo sapiens
Biochemical function: ubiquitin binding
Biological process: negative regulation of double-strand break repair
Cellular component: nucleus

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EC 3.4.19.12: Ubiquitinyl hydrolase 1

Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
  • Ubiquitin C-terminal hydrolase
  • Ubiquitin carboxyl-terminal hydrolase
  • Ubiquitin thiolesterase
  • Yeast ubiquitin hydrolase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF10275
Domain description: Peptidase C65 Otubain
Occurring in:
  1. Ubiquitin thioesterase OTUB2
The deposited structure of PDB entry 5qiy contains 1 copy of Pfam domain PF10275 (Peptidase C65 Otubain) in Ubiquitin thioesterase OTUB2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR042467
Domain description: Peptidase C65, otubain, subdomain 2
Occurring in:
  1. Ubiquitin thioesterase OTUB2
IPR003323
Domain description: OTU domain
Occurring in:
  1. Ubiquitin thioesterase OTUB2
IPR042468
Domain description: Peptidase C65, otubain, subdomain 1
Occurring in:
  1. Ubiquitin thioesterase OTUB2
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Ubiquitin thioesterase OTUB2
IPR019400
Domain description: Peptidase C65, otubain
Occurring in:
  1. Ubiquitin thioesterase OTUB2
IPR016615
Domain description: Ubiquitin thioesterase Otubain
Occurring in:
  1. Ubiquitin thioesterase OTUB2

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