› 5qhz

X-ray diffraction
1.15Å resolution

PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000385a

Released:
DOI: 10.2210/pdb5qhz/pdb
PDB 5qhz coloured by chain and viewed from the front.
PDB 5qhz coloured by chain and viewed from the side.
PDB 5qhz coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Schuller M, Talon R, Krojer T, Brandao-Neto J, Douangamath A, Zhang R, von Delft F, Schuler H, Kessler B, Knapp S, Bountra C, Arrowsmith CH, Edwards A, Elkins J

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein mono-ADP-ribosyltransferase PARP14 Chain: A
Molecule details ›
Chain: A
Length: 183 amino acids
Theoretical weight: 19.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q460N5 (Residues: 1208-1388; Coverage: 10%)
Gene names: BAL2, KIAA1268, PARP14
Sequence domains: Macro domain
Structure domains: Leucine Aminopeptidase, subunit E, domain 1

Ligands and Environments

3 bound ligands:
Ligand CL 2 x CL
Ligand DMS 2 x DMS
Ligand GT7 1 x GT7
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 34.399Å b: 41.583Å c: 111.38Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.141 0.14 0.174
Expression system: Escherichia coli

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