Structure analysis

Ligand binding to FARNESOID-X-RECEPTOR

X-ray diffraction
2.2Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 11976.22 Å2
Buried surface area: 1111.67 Å2
Dissociation area: 555.84 Å2
Dissociation energy (ΔGdiss): 2 kcal/mol
Dissociation entropy (TΔSdiss): 7.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172398
Assembly 2
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Multimeric state: hetero dimer
Accessible surface area: 11862.29 Å2
Buried surface area: 1139.41 Å2
Dissociation area: 569.71 Å2
Dissociation energy (ΔGdiss): 4.29 kcal/mol
Dissociation entropy (TΔSdiss): 7.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172398
Assembly 3
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Multimeric state: hetero dimer
Accessible surface area: 11953.96 Å2
Buried surface area: 1117.93 Å2
Dissociation area: 558.96 Å2
Dissociation energy (ΔGdiss): 2.02 kcal/mol
Dissociation entropy (TΔSdiss): 7.1 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172398
Assembly 4
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Multimeric state: hetero dimer
Accessible surface area: 11796.67 Å2
Buried surface area: 1086.74 Å2
Dissociation area: 543.37 Å2
Dissociation energy (ΔGdiss): 3.67 kcal/mol
Dissociation entropy (TΔSdiss): 7.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172398

Macromolecules

Chains: A, C, E, G
Length: 233 amino acids
Theoretical weight: 27.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96RI1 (Residues: 258-486; Coverage: 47%)
Gene names: BAR, FXR, HRR1, NR1H4, RIP14
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor

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Chains: B, D, F, H
Length: 14 amino acids
Theoretical weight: 1.79 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 744-757; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1

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