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Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(3-chlorophenyl)sulfonyl-3-[3-[3-[(3-chlorophenyl)sulfonylcarbamoylamino]propoxy]propyl]urea

X-ray diffraction
1.9Å resolution
PDB entry 5pzr coloured by chain, front view.
PDB entry 5pzr coloured by chain, side view.
PDB entry 5pzr coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fructose-1,6-bisphosphatase 1
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Multimeric state: homo tetramer
Accessible surface area: 44211.85 Å2
Buried surface area: 16605.64 Å2
Dissociation area: 3,752.48 Å2
Dissociation energy (ΔGdiss): 26.53 kcal/mol
Dissociation entropy (TΔSdiss): 15.41 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-140663

Macromolecules

Fructose-1,6-bisphosphatase 1
Chains: A, B, C, D
Length: 338 amino acids
Theoretical weight: 36.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09467 (Residues: 1-338; Coverage: 100%)
Gene names: FBP, FBP1
Pfam:
InterPro:
CATH:
Fructose-1,6-bisphosphatase 1 in PDB entry 5pzr, assembly 1, front view.
Fructose-1,6-bisphosphatase 1 in PDB entry 5pzr, assembly 1, side view.
Fructose-1,6-bisphosphatase 1 in PDB entry 5pzr, assembly 1, top view.
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