PDBe 5pzr

X-ray diffraction
1.9Å resolution

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(3-chlorophenyl)sulfonyl-3-[3-[3-[(3-chlorophenyl)sulfonylcarbamoylamino]propoxy]propyl]urea

Released:
Source organism: Homo sapiens
Entry authors: Ruf A, Joseph C, Alker A, Banner D, Tetaz T, Benz J, Kuhn B, Rudolph MG, Yang H, Shao C, Burley SK

Function and Biology Details

Reaction catalysed:
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cDNA FLJ75786, highly similar to Homo sapiens fructose-1,6-bisphosphatase 1 (FBP1), mRNA Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 338 amino acids
Theoretical weight: 36.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW Q2TU34 (Residues: 1-338; Coverage: 100%)
Gene names: FBP1, hCG_1640493
Sequence domains: Fructose-1-6-bisphosphatase, N-terminal domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 67.306Å b: 83.148Å c: 277.665Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.178 0.218
Expression system: Escherichia coli