PDBe 5oww

X-ray diffraction
1.5Å resolution

Crystal structure of human BRD4(1) bromodomain in complex with UT22B

Released:
Source organism: Homo sapiens
Entry authors: Zhu J, Caflisch A

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 127 amino acids
Theoretical weight: 15.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 59.877Å b: 41.924Å c: 109.416Å
α: 90° β: 92.03° γ: 90°
R-values:
R R work R free
0.184 0.184 0.203
Expression system: Escherichia coli