› 5owb

X-ray diffraction
1.65Å resolution

Crystal structure of the human BRPF1 bromodomain in complex with DSPBP1004

Released:
DOI: 10.2210/pdb5owb/pdb
PDB 5owb coloured by chain and viewed from the front.
PDB 5owb coloured by chain and viewed from the side.
PDB 5owb coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Zhu J, Spiliotopoulos D, Caflisch A

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peregrin Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 13.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55201 (Residues: 626-740; Coverage: 10%)
Gene names: BR140, BRPF1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand NO3 1 x NO3
Ligand AYW 1 x AYW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3221
Unit cell:
a: 60.426Å b: 60.426Å c: 63.468Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.178 0.175 0.204
Expression system: Escherichia coli

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