X-ray diffraction
2.3Å resolution

Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor compound 21


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Son of sevenless homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 490 amino acids
Theoretical weight: 57.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q07889 (Residues: 560-1049; Coverage: 37%)
Gene name: SOS1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 41.413Å b: 85.362Å c: 176.221Å
α: 90° β: 90° γ: 90°
R R work R free
0.263 0.26 0.33
Expression system: Escherichia coli