5otw

X-ray diffraction
2.1Å resolution

Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Hcs/Thr11Cys

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glucagon-like peptide 1 receptor Chains: A, C
Molecule details ›
Chains: A, C
Length: 116 amino acids
Theoretical weight: 13.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43220 (Residues: 24-139; Coverage: 26%)
Gene name: GLP1R
Sequence domains: Hormone receptor domain
Glucagon-like peptide 1(7-37) Chains: B, D
Molecule details ›
Chains: B, D
Length: 31 amino acids
Theoretical weight: 3.41 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01275 (Residues: 98-128; Coverage: 19%)
Gene name: GCG
Sequence domains: Peptide hormone

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-X
Spacegroup: P21
Unit cell:
a: 39.26Å b: 81.2Å c: 42.74Å
α: 90° β: 98.67° γ: 90°
R-values:
R R work R free
0.189 0.184 0.239
Expression systems:
  • Escherichia coli
  • Not provided