5oo1

X-ray diffraction
2Å resolution

Cdk2(F80C, C177A) covalent adduct with C37 at F80C

Released:
Source organism: Homo sapiens
Entry authors: Craven G, Morgan RML, Mann DJ

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 303 amino acids
Theoretical weight: 34.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 49.576Å b: 66.486Å c: 70.053Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.185 0.236
Expression system: Escherichia coli