5oh3

X-ray diffraction
2.1Å resolution

Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Ethosuximide

Released:
Primary publication:
Chemical Ligand Space of Cereblon.
OpenAccess logo ACS Omega 3 11163-11171 (2018)
PMID: 31459225

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CULT domain-containing protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 125 amino acids
Theoretical weight: 13.7 KDa
Source organism: Magnetospirillum gryphiswaldense
Expression system: Escherichia coli
UniProt:
  • Canonical: A4TVL0 (Residues: 1-124; Coverage: 100%)
Gene name: MGR_0879

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 56.88Å b: 59.79Å c: 88.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.179 0.231
Expression system: Escherichia coli