› 5oh1

X-ray diffraction
1.7Å resolution

Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Aminoglutethimide

Released:
DOI: 10.2210/pdb5oh1/pdb
PDB entry 5oh1 coloured by chain, front view.
PDB entry 5oh1 coloured by chain, side view.
PDB entry 5oh1 coloured by chain, top view.
Source organism: Magnetospirillum gryphiswaldense
Primary publication:
Chemical Ligand Space of Cereblon.
Boichenko I, Bär K, Deiss S, Heim C, Albrecht R, Lupas AN, Hernandez Alvarez B, Hartmann MD
ACS Omega 3 11163-11171 (2018)
PMID: 31459225

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107419 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CULT domain-containing protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 125 amino acids
Theoretical weight: 13.7 KDa
Source organism: Magnetospirillum gryphiswaldense
Expression system: Escherichia coli
UniProt:
  • Canonical: A4TVL0 (Residues: 1-124; Coverage: 100%)
Gene name: MGR_0879

Ligands and Environments

3 bound ligands:
Ligand ZN 3 x ZN
Ligand EF2 2 x EF2
Ligand 9UQ 1 x 9UQ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 56.831Å b: 60.446Å c: 88.523Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.166 0.21
Expression system: Escherichia coli

Quick links

Citations

4 review citations

PROTACs- a game-changing technology.
Konstantinidou et al. (2019)
3 more

2 mentions without citation

Chemical Ligand Space of Cereblon.
Boichenko et al. (2018)
1 more