X-ray diffraction
2.5Å resolution

Crystal structure of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at 2.5 Angstrom; internal aldimine with PLP in the active site


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Alanine--glyoxylate aminotransferase Chain: A
Molecule details ›
Chain: A
Length: 392 amino acids
Theoretical weight: 43.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P21549 (Residues: 1-392; Coverage: 100%)
Gene names: AGT1, AGXT, SPAT
Sequence domains: Aminotransferase class-V
Structure domains:

Ligands and Environments

Cofactor: Ligand PLP 1 x PLP
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P41212
Unit cell:
a: 90.673Å b: 90.673Å c: 141.197Å
α: 90° β: 90° γ: 90°
R R work R free
0.257 0.255 0.294
Expression system: Escherichia coli