X-ray diffraction
3.2Å resolution

Structural basis for OXA-48 dimerization

Source organism: Klebsiella pneumoniae
Entry authors: Lund BA, Nesheim BHB, Leiros HKS

Function and Biology Details

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Beta-lactamase Chains: A, B
Molecule details ›
Chains: A, B
Length: 243 amino acids
Theoretical weight: 28.14 KDa
Source organism: Klebsiella pneumoniae
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q6XEC0 (Residues: 23-265; Coverage: 100%)
Gene names: KPE71T_00045, SAMEA3727643_05844, bla OXA-48, blaOXA-48, bla_4
Sequence domains: Penicillin binding protein transpeptidase domain
Structure domains: DD-peptidase/beta-lactamase superfamily

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P6522
Unit cell:
a: 120.151Å b: 120.151Å c: 160.107Å
α: 90° β: 90° γ: 120°
R R work R free
0.186 0.182 0.242
Expression system: Escherichia coli BL21(DE3)