Function and Biology

Molecular basis of human kinesin-8 function and inhibition

Source organisms:
Biochemical function: GTP binding
Biological process: microtubule cytoskeleton organization
Cellular component: microtubule

Sequence families

Pfam Protein families (Pfam)
PF00091
Domain description: Tubulin/FtsZ family, GTPase domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
1 copy of Pfam domain PF00091 (Tubulin/FtsZ family, GTPase domain) in Tubulin alpha-1B chain in PDB 5ocu.
2 copies of Pfam domain PF00091 (Tubulin/FtsZ family, GTPase domain) in Tubulin beta chain in PDB 5ocu.

PF03953
Domain description: Tubulin C-terminal domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
1 copy of Pfam domain PF03953 (Tubulin C-terminal domain) in Tubulin alpha-1B chain in PDB 5ocu.
2 copies of Pfam domain PF03953 (Tubulin C-terminal domain) in Tubulin beta chain in PDB 5ocu.

PF00225
Domain description: Kinesin motor domain
Occurring in:
  1. Kinesin-like protein KIF18A
1 copy of Pfam domain PF00225 (Kinesin motor domain) in Kinesin-like protein KIF18A in PDB 5ocu.

InterPro InterPro annotations
IPR000217
Domain description: Tubulin
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR002452
Domain description: Alpha tubulin
Occurring in:
  1. Tubulin alpha-1B chain
IPR002453
Domain description: Beta tubulin
Occurring in:
  1. Tubulin beta chain
IPR001752
Domain description: Kinesin motor domain
Occurring in:
  1. Kinesin-like protein KIF18A
IPR003008
Domain description: Tubulin/FtsZ, GTPase domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR036525
Domain description: Tubulin/FtsZ, GTPase domain superfamily
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR018316
Domain description: Tubulin/FtsZ, 2-layer sandwich domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR037103
Domain description: Tubulin/FtsZ, C-terminal domain superfamily
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR023123
Domain description: Tubulin, C-terminal
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR008280
Domain description: Tubulin/FtsZ, C-terminal
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR027640
Domain description: Kinesin-like protein
Occurring in:
  1. Kinesin-like protein KIF18A
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Kinesin-like protein KIF18A
IPR036961
Domain description: Kinesin motor domain superfamily
Occurring in:
  1. Kinesin-like protein KIF18A