› 5och

X-ray diffraction
3.4Å resolution

The crystal structure of human ABCB8 in an outward-facing state

Released:
DOI: 10.2210/pdb5och/pdb
PDB 5och coloured by chain and viewed from the front.
PDB 5och coloured by chain and viewed from the side.
PDB 5och coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Faust B, Pike ACW, Shintre CA, Quiqley AM, Chu A, Barr A, Shrestha L, Mukhopadhyay S, Borkowska O, Chalk R, Burgess-Brown NA, Arrowsmith CH, Edwards AM, Bountra C, Carpenter EP, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
homo dimer
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Mitochondrial potassium channel ATP-binding subunit Chains: A, C, D
Molecule details ›
Chains: A, C, D
Length: 612 amino acids
Theoretical weight: 66.54 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NUT2 (Residues: 110-714; Coverage: 82%)
Gene names: ABCB8, MABC1, MITOSUR
Sequence domains:
Mitochondrial potassium channel ATP-binding subunit Chain: B
Molecule details ›
Chain: B
Length: 612 amino acids
Theoretical weight: 66.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NUT2 (Residues: 110-714; Coverage: 82%)
Gene names: ABCB8, MABC1, MITOSUR
Sequence domains:
Mitochondrial potassium channel ATP-binding subunit Chain: E
Molecule details ›
Chain: E
Length: 612 amino acids
Theoretical weight: 66.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NUT2 (Residues: 110-714; Coverage: 82%)
Gene names: ABCB8, MABC1, MITOSUR
Sequence domains:
Mitochondrial potassium channel ATP-binding subunit Chains: F, G
Molecule details ›
Chains: F, G
Length: 612 amino acids
Theoretical weight: 66.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NUT2 (Residues: 110-714; Coverage: 82%)
Gene names: ABCB8, MABC1, MITOSUR
Sequence domains:
Mitochondrial potassium channel ATP-binding subunit Chain: H
Molecule details ›
Chain: H
Length: 612 amino acids
Theoretical weight: 66.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NUT2 (Residues: 110-714; Coverage: 82%)
Gene names: ABCB8, MABC1, MITOSUR
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ADP 8 x ADP
Ligand MG 8 x MG
Ligand Y01 7 x Y01
1 modified residue:
Ligand YCM 11 x YCM

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21
Unit cell:
a: 181.08Å b: 98.5Å c: 214.87Å
α: 90° β: 90.5° γ: 90°
R-values:
R R work R free
0.232 0.231 0.251
Expression system: Spodoptera frugiperda

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