5och

X-ray diffraction
3.4Å resolution

The crystal structure of human ABCB8 in an outward-facing state

Released:
Source organism: Homo sapiens
Entry authors: Faust B, Pike ACW, Shintre CA, Quiqley AM, Chu A, Barr A, Shrestha L, Mukhopadhyay S, Borkowska O, Chalk R, Burgess-Brown NA, Arrowsmith CH, Edwards AM, Bountra C, Carpenter EP, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
homo dimer
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Mitochondrial potassium channel ATP-binding subunit Chains: A, C, D
Molecule details ›
Chains: A, C, D
Length: 612 amino acids
Theoretical weight: 66.54 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NUT2 (Residues: 110-714; Coverage: 82%)
Gene names: ABCB8, MABC1, MITOSUR
Sequence domains:
Mitochondrial potassium channel ATP-binding subunit Chain: B
Molecule details ›
Chain: B
Length: 612 amino acids
Theoretical weight: 66.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NUT2 (Residues: 110-714; Coverage: 82%)
Gene names: ABCB8, MABC1, MITOSUR
Sequence domains:
Mitochondrial potassium channel ATP-binding subunit Chain: E
Molecule details ›
Chain: E
Length: 612 amino acids
Theoretical weight: 66.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NUT2 (Residues: 110-714; Coverage: 82%)
Gene names: ABCB8, MABC1, MITOSUR
Sequence domains:
Mitochondrial potassium channel ATP-binding subunit Chains: F, G
Molecule details ›
Chains: F, G
Length: 612 amino acids
Theoretical weight: 66.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NUT2 (Residues: 110-714; Coverage: 82%)
Gene names: ABCB8, MABC1, MITOSUR
Sequence domains:
Mitochondrial potassium channel ATP-binding subunit Chain: H
Molecule details ›
Chain: H
Length: 612 amino acids
Theoretical weight: 66.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NUT2 (Residues: 110-714; Coverage: 82%)
Gene names: ABCB8, MABC1, MITOSUR
Sequence domains:

Ligands and Environments

3 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21
Unit cell:
a: 181.08Å b: 98.5Å c: 214.87Å
α: 90° β: 90.5° γ: 90°
R-values:
R R work R free
0.232 0.231 0.251
Expression system: Spodoptera frugiperda