5oaq

X-ray diffraction
1.95Å resolution

TEAD4 COMPLEXED WITH YAP PEPTIDE AND MYRISTATE (COVALENTLY BOUND)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transcriptional enhancer factor TEF-3 Chain: A
Molecule details ›
Chain: A
Length: 220 amino acids
Theoretical weight: 25.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q15561 (Residues: 217-434; Coverage: 50%)
Gene names: RTEF1, TCF13L1, TEAD4, TEF3
Sequence domains: YAP binding domain
Transcriptional coactivator YAP1 Chain: L
Molecule details ›
Chain: L
Length: 41 amino acids
Theoretical weight: 4.65 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P46937 (Residues: 60-100; Coverage: 8%)
Gene names: YAP1, YAP65

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P41212
Unit cell:
a: 59.012Å b: 59.012Å c: 159.559Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.229 0.252
Expression systems:
  • Escherichia coli BL21
  • Not provided