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CELLOBIOHYDROLASE I (CEL7A) FROM HYPOCREA JECORINA WITH IMPROVED THERMAL STABILITY

Source organism: Trichoderma reesei
Biochemical function: hydrolase activity, hydrolyzing O-glycosyl compounds
Biological process: carbohydrate metabolic process
Cellular component: not assigned

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EC 3.2.1.91: Cellulose 1,4-beta-cellobiosidase (non-reducing end)

Reaction catalysed:
Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains
Systematic name:
4-beta-D-glucan cellobiohydrolase (non-reducing end)
Alternative Name(s):
  • 1,4-beta-cellobiohydrolase
  • 1,4-beta-glucan cellobiosidase
  • Avicelase
  • Beta-1,4-glucan cellobiohydrolase
  • Beta-1,4-glucan cellobiosylhydrolase
  • C1 cellulase
  • CBH 1
  • Cellobiohydrolase
  • Cellobiohydrolase I
  • Cellobiosidase
  • Exo-1,4-beta-D-glucanase
  • Exo-beta-1,4-glucan cellobiohydrolase
  • Exo-cellobiohydrolase
  • Exocellobiohydrolase
  • Exoglucanase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00840
Domain description: Glycosyl hydrolase family 7
Occurring in:
  1. Exoglucanase 1
The deposited structure of PDB entry 5oa5 contains 2 copies of Pfam domain PF00840 (Glycosyl hydrolase family 7) in Exoglucanase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001722
Domain description: Glycoside hydrolase, family 7
Occurring in:
  1. Exoglucanase 1
IPR013320
Domain description: Concanavalin A-like lectin/glucanase domain superfamily
Occurring in:
  1. Exoglucanase 1
IPR037019
Domain description: Glycoside hydrolase family 7, catalytic domain superfamily
Occurring in:
  1. Exoglucanase 1

Structure domain

CATH CATH domain
2.70.100.10
Class: Mainly Beta
Architecture: Distorted Sandwich
Topology: 1,4-Beta-D-Glucan Cellobiohydrolase I; Chain A
Homology: Glycoside hydrolase, family 7, domain
Occurring in:
  1. Exoglucanase 1
The deposited structure of PDB entry 5oa5 contains 2 copies of CATH domain 2.70.100.10 (1,4-Beta-D-Glucan Cellobiohydrolase I; Chain A) in Exoglucanase 1. Showing 1 copy in chain A.

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