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Discovery of CDZ173 (leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors

X-ray diffraction
2.9Å resolution
PDB entry 5o83 coloured by chain, front view.
PDB entry 5o83 coloured by chain, side view.
PDB entry 5o83 coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-128718

Macromolecules

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Chain: A
Length: 941 amino acids
Theoretical weight: 107.95 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O35904 (Residues: 106-507, 509-1043; Coverage: 90%)
Gene name: Pik3cd
Pfam:
InterPro:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform in PDB entry 5o83, assembly 1, front view.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform in PDB entry 5o83, assembly 1, side view.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform in PDB entry 5o83, assembly 1, top view.
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