5o7p

X-ray diffraction
4.5Å resolution

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Receptor tyrosine-protein kinase erbB-3 Chain: C
Molecule details ›
Chain: C
Length: 649 amino acids
Theoretical weight: 71.6 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P21860 (Residues: 1-643; Coverage: 47%)
  • Best match: P21860-3 (Residues: 1-330)
Gene names: ERBB3, HER3
Sequence domains:
MF3178 FAB light chain Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
MF3178 FAB heavy chain Chain: B
Molecule details ›
Chain: B
Length: 250 amino acids
Theoretical weight: 26.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P6422
Unit cell:
a: 141.131Å b: 141.131Å c: 320.817Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.25 0.247 0.296
Expression system: Homo sapiens