X-ray diffraction
1.85Å resolution

Crystal structure of the human BRPF1 bromodomain in complex with BZ053

Source organism: Homo sapiens
Primary publication:
Structure-based discovery of selective BRPF1 bromodomain inhibitors.
Eur J Med Chem 155 337-352 (2018)
PMID: 29902720

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Peregrin Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 13.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P55201 (Residues: 626-740; Coverage: 10%)
Gene names: BR140, BRPF1
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P3221
Unit cell:
a: 61.027Å b: 61.027Å c: 63.787Å
α: 90° β: 90° γ: 120°
R R work R free
0.194 0.19 0.235
Expression system: Escherichia coli