› 5o4t

X-ray diffraction
1.5Å resolution

Crystal structure of the human BRPF1 bromodomain in complex with BZ061

Released:
DOI: 10.2210/pdb5o4t/pdb
PDB 5o4t coloured by chain and viewed from the front.
PDB 5o4t coloured by chain and viewed from the side.
PDB 5o4t coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structure-based discovery of selective BRPF1 bromodomain inhibitors.
Zhu J, Zhou C, Caflisch A
Eur J Med Chem 155 337-352 (2018)
PMID: 29902720

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peregrin Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 13.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55201 (Residues: 626-740; Coverage: 10%)
Gene names: BR140, BRPF1
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand 9KT 1 x 9KT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P3221
Unit cell:
a: 60.639Å b: 60.639Å c: 63.465Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.185 0.182 0.212
Expression system: Escherichia coli

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Citations

2 review citations

Functional Roles of Bromodomain Proteins in Cancer.
Boyson et al. (2021)
1 more