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Human KRAS in complex with darpin K27

X-ray diffraction
2.19Å resolution
PDB entry 5o2t coloured by chain, front view.
PDB entry 5o2t coloured by chain, side view.
PDB entry 5o2t coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: GTPase KRas, N-terminally processed
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Multimeric state: hetero dimer
Accessible surface area: 13077.3 Å2
Buried surface area: 3205.1 Å2
Dissociation area: 930.56 Å2
Dissociation energy (ΔGdiss): 1.69 kcal/mol
Dissociation entropy (TΔSdiss): 11.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134004

Macromolecules

GTPase KRas, N-terminally processed
Chain: A
Length: 169 amino acids
Theoretical weight: 19.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01116 (Residues: 1-166; Coverage: 88%)
Gene names: KRAS, KRAS2, RASK2
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
GTPase KRas, N-terminally processed in PDB entry 5o2t, assembly 1, front view.
GTPase KRas, N-terminally processed in PDB entry 5o2t, assembly 1, side view.
GTPase KRas, N-terminally processed in PDB entry 5o2t, assembly 1, top view.
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darpin 55
Chain: B
Length: 187 amino acids
Theoretical weight: 20.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
CATH: Ankyrin repeat-containing domain
darpin 55 in PDB entry 5o2t, assembly 1, front view.
darpin 55 in PDB entry 5o2t, assembly 1, side view.
darpin 55 in PDB entry 5o2t, assembly 1, top view.
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