› 5o1v

X-ray diffraction
1.72Å resolution

Crystal structure of WNK3 kinase domain in a monophosphorylated apo state (A-loop swapped)

Released:
DOI: 10.2210/pdb5o1v/pdb
PDB entry 5o1v coloured by chain, front view.
PDB entry 5o1v coloured by chain, side view.
PDB entry 5o1v coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pinkas DM, Bufton JC, Kupinska K, Wang D, Fairhead M, Kopec J, Sethi R, Dixon-Clarke SE, Chalk R, Berridge G, Burgess-Brown NA, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Bullock A, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189842 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase WNK3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 285 amino acids
Theoretical weight: 32.73 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BYP7 (Residues: 132-414; Coverage: 16%)
Gene names: KIAA1566, PRKWNK3, WNK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand EDO 16 x EDO
1 modified residue:
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 58.966Å b: 67.484Å c: 79.895Å
α: 90° β: 94.56° γ: 90°
R-values:
R R work R free
0.175 0.173 0.208
Expression system: Spodoptera frugiperda

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