X-ray diffraction
1.74Å resolution

Crystal structure of Phosphopantetheine adenylyltransferase from Mycobacterium abcessus in complex with 3-Bromo-1H-indazole-5-carboxylic acid (Fragment 2)


Function and Biology Details

Reaction catalysed:
ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Phosphopantetheine adenylyltransferase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 162 amino acids
Theoretical weight: 17.48 KDa
Source organism: Mycobacteroides abscessus ATCC 19977
Expression system: Escherichia coli BL21(DE3)
  • Canonical: B1MDL6 (Residues: 1-161; Coverage: 100%)
Gene names: MAB_3259c, coaD
Sequence domains: Cytidylyltransferase-like
Structure domains: HUPs

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2221
Unit cell:
a: 76.069Å b: 125.171Å c: 119.435Å
α: 90° β: 90° γ: 90°
R R work R free
0.199 0.198 0.229
Expression system: Escherichia coli BL21(DE3)