› 5nz1

X-ray diffraction
2.33Å resolution

Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with sutezolid

Released:
DOI: 10.2210/pdb5nz1/pdb
PDB 5nz1 coloured by chain and viewed from the front.
PDB 5nz1 coloured by chain and viewed from the side.
PDB 5nz1 coloured by chain and viewed from the top.
Source organism: Mycobacterium tuberculosis H37Rv
Entry authors: Mendes V, Blaszczyk M, Nikiforov PO, Blundell TL

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH-type transcriptional regulator EthR Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 228 amino acids
Theoretical weight: 25.26 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WMC1 (Residues: 2-216; Coverage: 100%)
Gene names: Rv3855, etaR, ethR

Ligands and Environments

1 bound ligand:
Ligand 9EN 3 x 9EN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 85.858Å b: 144.841Å c: 150.741Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.191 0.244
Expression system: Escherichia coli BL21(DE3)

Quick links