5nw7

X-ray diffraction
1.85Å resolution

Crystal structure of candida albicans phosphomannose isomerase in complex with inhibitor

Released:

Function and Biology Details

Reaction catalysed:
D-mannose 6-phosphate = D-fructose 6-phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mannose-6-phosphate isomerase Chain: A
Molecule details ›
Chain: A
Length: 455 amino acids
Theoretical weight: 50.53 KDa
Source organism: Candida albicans
Expression system: Escherichia coli
UniProt:
  • Canonical: P34948 (Residues: 1-441; Coverage: 100%)
Gene names: CAALFM_C209640WA, CaO19.1390, MANA, PMI1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21212
Unit cell:
a: 87.97Å b: 107.86Å c: 44.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.171 0.207
Expression system: Escherichia coli