5nvn

X-ray diffraction
1.9Å resolution

Crystal structure of the human 4EHP-4E-BP1 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Eukaryotic translation initiation factor 4E type 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 189 amino acids
Theoretical weight: 21.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O60573 (Residues: 52-234; Coverage: 75%)
Gene names: EIF4E2, EIF4EL3
Sequence domains: Eukaryotic initiation factor 4E
Structure domains: RNA Cap, Translation Initiation Factor Eif4e
Eukaryotic translation initiation factor 4E-binding protein 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 38 amino acids
Theoretical weight: 4.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13541 (Residues: 50-83; Coverage: 29%)
Gene name: EIF4EBP1

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 38.4Å b: 83.39Å c: 70.5Å
α: 90° β: 104.28° γ: 90°
R-values:
R R work R free
0.228 0.226 0.251
Expression system: Escherichia coli BL21(DE3)