X-ray diffraction
2.26Å resolution

Substrate-bound outward-open state of a Na+-coupled sialic acid symporter reveals a novel Na+-site


Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Putative sodium:solute symporter Chain: A
Molecule details ›
Chain: A
Length: 496 amino acids
Theoretical weight: 54.28 KDa
Source organism: Proteus mirabilis HI4320
Expression system: Escherichia coli
  • Canonical: B4EZY7 (Residues: 1-496; Coverage: 100%)
Gene name: PMI2976
Sequence domains: Sodium:solute symporter family

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Unit cell:
a: 48.788Å b: 97.764Å c: 151.69Å
α: 90° β: 90° γ: 90°
R R work R free
0.226 0.224 0.261
Expression system: Escherichia coli