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Torpedo californica acetylcholinesterase in complex with a chlorotacrine-tryptophan hybrid inhibitor

X-ray diffraction
2.5Å resolution
PDB entry 5nuu coloured by chain, front view.
PDB entry 5nuu coloured by chain, side view.
PDB entry 5nuu coloured by chain, top view.
Source organism: Tetronarce californica
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Acetylcholinesterase
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Multimeric state: homo dimer
Accessible surface area: 39639.69 Å2
Buried surface area: 3547.25 Å2
Dissociation area: 985.5 Å2
Dissociation energy (ΔGdiss): 1.04 kcal/mol
Dissociation entropy (TΔSdiss): 14.55 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-137375

Macromolecules

Acetylcholinesterase
Chain: A
Length: 543 amino acids
Theoretical weight: 61.33 KDa
Source organism: Tetronarce californica
UniProt:
  • Canonical: P04058 (Residues: 22-564; Coverage: 96%)
Gene name: ache
Pfam: Carboxylesterase family
InterPro:
Acetylcholinesterase in PDB entry 5nuu, assembly 1, front view.
Acetylcholinesterase in PDB entry 5nuu, assembly 1, side view.
Acetylcholinesterase in PDB entry 5nuu, assembly 1, top view.
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