PDBe 5nu1

X-ray diffraction
1.85Å resolution

Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor ROR-gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 257 amino acids
Theoretical weight: 29.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51449 (Residues: 263-518; Coverage: 49%)
Gene names: NR1F3, RORC, RORG, RZRG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Nuclear receptor-interacting protein 1 Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 20 amino acids
Theoretical weight: 2.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P48552 (Residues: 493-512; Coverage: 2%)
Gene name: NRIP1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 48.389Å b: 68.802Å c: 82.866Å
α: 90° β: 102.92° γ: 90°
R-values:
R R work R free
0.236 0.235 0.256
Expression system: Escherichia coli BL21(DE3)