› 5ntp

X-ray diffraction
1.7Å resolution

Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds

Released:
DOI: 10.2210/pdb5ntp/pdb
PDB 5ntp coloured by chain and viewed from the front.
PDB 5ntp coloured by chain and viewed from the side.
PDB 5ntp coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structural states of ROR��t: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds.
Kallen J, Izaac A, Be C, Arista L, Orain D, Kaupmann K, Guntermann C, Hoegenauer K, Hintermann S
ChemMedChem (2017)
PMID: 28590087

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor ROR-gamma Chain: A
Molecule details ›
Chain: A
Length: 238 amino acids
Theoretical weight: 27.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51449 (Residues: 263-499; Coverage: 46%)
Gene names: NR1F3, RORC, RORG, RZRG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 98E 1 x 98E
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 72.31Å b: 128.372Å c: 46.304Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.194 0.227
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

ROR: Nuclear Receptor for Melatonin or Not?
Ma et al. (2021)
3 more