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Mtb TMK crystal structure in complex with compound 3

X-ray diffraction
2.2Å resolution
PDB entry 5nrn coloured by chain, front view.
PDB entry 5nrn coloured by chain, side view.
PDB entry 5nrn coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Thymidylate kinase
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Multimeric state: homo dimer
Accessible surface area: 16704.94 Å2
Buried surface area: 2519.44 Å2
Dissociation area: 822.97 Å2
Dissociation energy (ΔGdiss): 8.71 kcal/mol
Dissociation entropy (TΔSdiss): 12.32 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-161736

Macromolecules

Thymidylate kinase
Chains: A, B
Length: 214 amino acids
Theoretical weight: 22.66 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WKE1 (Residues: 1-214; Coverage: 100%)
Gene names: Rv3247c, tmk
Pfam: Thymidylate kinase
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Thymidylate kinase in PDB entry 5nrn, assembly 1, front view.
Thymidylate kinase in PDB entry 5nrn, assembly 1, side view.
Thymidylate kinase in PDB entry 5nrn, assembly 1, top view.
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