› › Function and Biology

2.22A STRUCTURE OF THIOPHENE2 AND GSK945237 WITH S.AUREUS DNA GYRASE AND DNA

Source organism: Staphylococcus aureus subsp. aureus N315
Biochemical function: ATP binding
Biological process: DNA topological change
Cellular component: not assigned

Quick links

EC 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing)

Reaction catalysed:
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Systematic name:
DNA topoisomerase (ATP-hydrolyzing)
Alternative Name(s):
  • DNA gyrase
  • DNA topoisomerase II
  • Type II DNA topoisomerase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00521
Domain description: DNA gyrase/topoisomerase IV, subunit A
Occurring in:
  1. DNA gyrase subunit A; DNA gyrase subunit B
The deposited structure of PDB entry 5npp contains 2 copies of Pfam domain PF00521 (DNA gyrase/topoisomerase IV, subunit A) in DNA gyrase subunit A. Showing 1 copy in chain A [auth B].

PF00986
Domain description: DNA gyrase B subunit, carboxyl terminus
Occurring in:
  1. DNA gyrase subunit A; DNA gyrase subunit B
The deposited structure of PDB entry 5npp contains 2 copies of Pfam domain PF00986 (DNA gyrase B subunit, carboxyl terminus) in DNA gyrase subunit A. Showing 1 copy in chain A [auth B].

PF01751
Domain description: Toprim domain
Occurring in:
  1. DNA gyrase subunit A; DNA gyrase subunit B
The deposited structure of PDB entry 5npp contains 2 copies of Pfam domain PF01751 (Toprim domain) in DNA gyrase subunit A. Showing 1 copy in chain A [auth B].

InterPro InterPro annotations
IPR002205
Domain description: DNA topoisomerase, type IIA, domain A
Occurring in:
  1. DNA gyrase subunit A; DNA gyrase subunit B
IPR006171
Domain description: TOPRIM domain
Occurring in:
  1. DNA gyrase subunit A; DNA gyrase subunit B
IPR013757
Domain description: DNA topoisomerase, type IIA, alpha-helical domain superfamily
Occurring in:
  1. DNA gyrase subunit A; DNA gyrase subunit B
IPR013758
Domain description: DNA topoisomerase, type IIA, domain A, alpha-beta
Occurring in:
  1. DNA gyrase subunit A; DNA gyrase subunit B
IPR002288
Domain description: DNA gyrase B subunit, C-terminal
Occurring in:
  1. DNA gyrase subunit A; DNA gyrase subunit B
IPR018522
Domain description: DNA topoisomerase, type IIA, conserved site
Occurring in:
  1. DNA gyrase subunit A; DNA gyrase subunit B
IPR034160
Domain description: DNA gyrase subunit B, TOPRIM domain
Occurring in:
  1. DNA gyrase subunit A; DNA gyrase subunit B
IPR013760
Domain description: DNA topoisomerase, type IIA-like domain superfamily
Occurring in:
  1. DNA gyrase subunit A; DNA gyrase subunit B
IPR013759
Domain description: DNA topoisomerase, type IIA, subunit B, C-terminal
Occurring in:
  1. DNA gyrase subunit A; DNA gyrase subunit B
IPR001241
Domain description: DNA topoisomerase, type IIA
Occurring in:
  1. DNA gyrase subunit A; DNA gyrase subunit B

Quick links