X-ray diffraction
2.8Å resolution

Trypanosoma brucei methionyl-tRNA synthetase in complex with a quinazolinone inhibitor


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Methionine--tRNA ligase Chains: A, B
Molecule details ›
Chains: A, B
Length: 536 amino acids
Theoretical weight: 60.67 KDa
Source organism: Trypanosoma brucei brucei TREU927
Expression system: Escherichia coli
  • Canonical: Q38C91 (Residues: 237-767; Coverage: 69%)
Gene name: Tb10.70.6470
Sequence domains: tRNA synthetases class I (M)
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 87.09Å b: 105.985Å c: 207.071Å
α: 90° β: 90° γ: 90°
R R work R free
0.197 0.195 0.23
Expression system: Escherichia coli