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Crystal structure of transketolase from Chlamydomonas reinhardtii in complex with TPP and Mg2+

Source organism: Chlamydomonas reinhardtii
Biochemical function: metal ion binding
Biological process: pentose-phosphate shunt
Cellular component: cytosol

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EC 2.2.1.1: Transketolase

Reaction catalysed:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
Systematic name:
Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase
Alternative Name(s):
  • Glycoaldehyde transferase
  • Glycolaldehydetransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02780
Domain description: Transketolase, C-terminal domain
Occurring in:
  1. transketolase
The deposited structure of PDB entry 5nd5 contains 2 copies of Pfam domain PF02780 (Transketolase, C-terminal domain) in transketolase. Showing 1 copy in chain A.

PF02779
Domain description: Transketolase, pyrimidine binding domain
Occurring in:
  1. transketolase
The deposited structure of PDB entry 5nd5 contains 2 copies of Pfam domain PF02779 (Transketolase, pyrimidine binding domain) in transketolase. Showing 1 copy in chain A.

PF00456
Domain description: Transketolase, thiamine diphosphate binding domain
Occurring in:
  1. transketolase
The deposited structure of PDB entry 5nd5 contains 2 copies of Pfam domain PF00456 (Transketolase, thiamine diphosphate binding domain) in transketolase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005474
Domain description: Transketolase, N-terminal
Occurring in:
  1. transketolase
IPR009014
Domain description: Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
Occurring in:
  1. transketolase
IPR005475
Domain description: Transketolase-like, pyrimidine-binding domain
Occurring in:
  1. transketolase
IPR029061
Domain description: Thiamin diphosphate-binding fold
Occurring in:
  1. transketolase
IPR033248
Domain description: Transketolase, C-terminal domain
Occurring in:
  1. transketolase
IPR020826
Domain description: Transketolase binding site
Occurring in:
  1. transketolase
IPR005478
Domain description: Transketolase, bacterial-like
Occurring in:
  1. transketolase
IPR033247
Domain description: Transketolase family
Occurring in:
  1. transketolase

Structure domains

CATH CATH domains
3.40.50.970
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. transketolase
The deposited structure of PDB entry 5nd5 contains 4 copies of CATH domain 3.40.50.970 (Rossmann fold) in transketolase. Showing 2 copies in chain A.
3.40.50.920
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. transketolase
The deposited structure of PDB entry 5nd5 contains 2 copies of CATH domain 3.40.50.920 (Rossmann fold) in transketolase. Showing 1 copy in chain A.

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