› 5nam

Solution NMR

NMR structure of TLR4 transmembrane domain (624-670) in DMPG/DHPC bicelles

Released:
DOI: 10.2210/pdb5nam/pdb
PDB entry 5nam coloured by chain, ensemble of 10 models, front view.
PDB entry 5nam coloured by chain, ensemble of 10 models, side view.
PDB entry 5nam coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Spatial structure of TLR4 transmembrane domain in bicelles provides the insight into the receptor activation mechanism.
Mineev KS, Goncharuk SA, Goncharuk MV, Volynsky PE, Novikova EV, Aresinev AS
Sci Rep 7 6864 (2017)
PMID: 28761155

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126152 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll-like receptor 4 Chain: A
Molecule details ›
Chain: A
Length: 48 amino acids
Theoretical weight: 5.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00206 (Residues: 623-670; Coverage: 6%)
Gene name: TLR4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 97%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

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Citations

2 review citations

A Structural Perspective on Calprotectin as a Ligand of Receptors Mediating Inflammation and Potential Drug Target.
Garcia et al. (2022)
1 more

6 mentions without citation

TLR4-Targeting Therapeutics: Structural Basis and Computer-Aided Drug Discovery Approaches.
Ain et al. (2020)
5 more