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Crystal structure of USP7 in complex with a potent, selective and reversible small-molecule inhibitor

Source organism: Homo sapiens
Biochemical function: cysteine-type deubiquitinase activity
Biological process: protein deubiquitination
Cellular component: not assigned

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EC 3.4.19.12: Ubiquitinyl hydrolase 1

Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
  • Ubiquitin C-terminal hydrolase
  • Ubiquitin carboxyl-terminal hydrolase
  • Ubiquitin thiolesterase
  • Yeast ubiquitin hydrolase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00443
Domain description: Ubiquitin carboxyl-terminal hydrolase
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 7
The deposited structure of PDB entry 5n9t contains 2 copies of Pfam domain PF00443 (Ubiquitin carboxyl-terminal hydrolase) in Ubiquitin carboxyl-terminal hydrolase 7. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR018200
Domain description: Ubiquitin specific protease, conserved site
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 7
IPR028889
Domain description: Ubiquitin specific protease domain
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 7
IPR001394
Domain description: Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 7
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 7

Structure domain

CATH CATH domain
2.20.210.10
Class: Mainly Beta
Architecture: Single Sheet
Topology: ubp-family deubiquitinating enzyme fold
Homology: ubp-family deubiquitinating enzyme superfamily
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 7
The deposited structure of PDB entry 5n9t contains 2 copies of CATH domain 2.20.210.10 (ubp-family deubiquitinating enzyme fold) in Ubiquitin carboxyl-terminal hydrolase 7. Showing 1 copy in chain A.

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