Function and Biology

Crystal structure of the Dbl-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-DH_4).

Source organisms:
Biochemical function: GTPase activator activity
Biological process: positive regulation of GTPase activity
Cellular component: not assigned

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

Sequence family

Pfam Protein family (Pfam)
PF00621
Domain description: RhoGEF domain
Occurring in:
  1. Breakpoint cluster region protein
The deposited structure of PDB entry 5n7e contains 1 copy of Pfam domain PF00621 (RhoGEF domain) in Breakpoint cluster region protein. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000219
Domain description: Dbl homology (DH) domain
Occurring in:
  1. Breakpoint cluster region protein
IPR003961
Domain description: Fibronectin type III
Occurring in:
  1. Mb(Bcr-DH_4)
IPR035899
Domain description: Dbl homology (DH) domain superfamily
Occurring in:
  1. Breakpoint cluster region protein
IPR001331
Domain description: Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Occurring in:
  1. Breakpoint cluster region protein
IPR037769
Domain description: Abr/Bcr
Occurring in:
  1. Breakpoint cluster region protein
IPR036116
Domain description: Fibronectin type III superfamily
Occurring in:
  1. Mb(Bcr-DH_4)
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Mb(Bcr-DH_4)

Structure domain

CATH CATH domain
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Mb(Bcr-DH_4)
The deposited structure of PDB entry 5n7e contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Mb(Bcr-DH_4). Showing 1 copy in chain A.