5n7d

X-ray diffraction
2.3Å resolution

MAGI-1 complexed with a RSK1 peptide

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Annexin A2; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 427 amino acids
Theoretical weight: 48.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07355 (Residues: 22-339; Coverage: 94%)
  • Canonical: Q96QZ7 (Residues: 455-558; Coverage: 7%)
Gene names: AIP3, ANX2, ANX2L4, ANXA2, BAIAP1, BAP1, CAL1H, LPC2D, MAGI1, TNRC19
Sequence domains:
Ribosomal protein S6 kinase alpha-1 Chain: C
Molecule details ›
Chain: C
Length: 49 amino acids
Theoretical weight: 5.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15418 (Residues: 688-735; Coverage: 7%)
Gene names: MAPKAPK1A, RPS6KA1, RSK1

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: C2
Unit cell:
a: 195.81Å b: 60.68Å c: 99.71Å
α: 90° β: 98.81° γ: 90°
R-values:
R R work R free
0.192 0.191 0.227
Expression system: Escherichia coli