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Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS910

X-ray diffraction
1.459Å resolution
PDB entry 5myc coloured by chain, front view.
PDB entry 5myc coloured by chain, side view.
PDB entry 5myc coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Leucine-rich repeat serine/threonine-protein kinase 2 and 14-3-3 protein sigma
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Multimeric state: hetero tetramer
Accessible surface area: 23522.75 Å2
Buried surface area: 6599.83 Å2
Dissociation area: 1,865.09 Å2
Dissociation energy (ΔGdiss): 18.89 kcal/mol
Dissociation entropy (TΔSdiss): 16.15 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-152161

Macromolecules

14-3-3 protein sigma
Chain: A
Length: 236 amino acids
Theoretical weight: 26.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31947 (Residues: 1-231; Coverage: 93%)
Gene names: HME1, SFN
Pfam: 14-3-3 protein
InterPro:
CATH: 14-3-3 domain
14-3-3 protein sigma in PDB entry 5myc, assembly 1, front view.
14-3-3 protein sigma in PDB entry 5myc, assembly 1, side view.
14-3-3 protein sigma in PDB entry 5myc, assembly 1, top view.
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Leucine-rich repeat serine/threonine-protein kinase 2
Chain: P
Length: 38 amino acids
Theoretical weight: 4.46 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q5S007 (Residues: 904-941; Coverage: 2%)
Gene names: LRRK2, PARK8
Leucine-rich repeat serine/threonine-protein kinase 2 in PDB entry 5myc, assembly 1, front view.
Leucine-rich repeat serine/threonine-protein kinase 2 in PDB entry 5myc, assembly 1, side view.
Leucine-rich repeat serine/threonine-protein kinase 2 in PDB entry 5myc, assembly 1, top view.
Molecule details ›

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