› 5mw7

X-ray diffraction
2.8Å resolution

Human Jagged2 C2-EGF3

Released:
DOI: 10.2210/pdb5mw7/pdb
PDB entry 5mw7 coloured by chain, front view.
PDB entry 5mw7 coloured by chain, side view.
PDB entry 5mw7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
Suckling RJ, Korona B, Whiteman P, Chillakuri C, Holt L, Handford PA, Lea SM
EMBO J 36 2204-2215 (2017)
PMID: 28572448

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195075 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein jagged-2 Chain: A
Molecule details ›
Chain: A
Length: 332 amino acids
Theoretical weight: 36.78 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q9Y219 (Residues: 27-348; Coverage: 27%)
Gene name: JAG2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand FUC 1 x FUC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 46.814Å b: 77.205Å c: 96.357Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.258 0.255 0.312
Expression system: Drosophila melanogaster

Quick links

Citations

8 review citations

Notch signaling pathway: architecture, disease, and therapeutics.
Zhou et al. (2022)
7 more

1 mention without citation

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
Suckling et al. (2017)