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Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds

Source organism: Homo sapiens
Biochemical function: dihydroorotate dehydrogenase (quinone) activity
Biological process: 'de novo' UMP biosynthetic process
Cellular component: membrane

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EC 1.3.5.2: Dihydroorotate dehydrogenase (quinone)

Reaction catalysed:
(S)-dihydroorotate + a quinone = orotate + a quinol
Systematic name:
(S)-dihydroorotate:quinone oxidoreductase
Alternative Name(s):
  • (S)-dihydroorotate:(acceptor) oxidoreductase
  • (S)-dihydroorotate:acceptor oxidoreductase
  • DHOD
  • DHODH
  • DHOdehase
  • Dihydroorotate:ubiquinone oxidoreductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01180
Domain description: Dihydroorotate dehydrogenase
Occurring in:
  1. Dihydroorotate dehydrogenase (quinone), mitochondrial
The deposited structure of PDB entry 5mut contains 1 copy of Pfam domain PF01180 (Dihydroorotate dehydrogenase) in Dihydroorotate dehydrogenase (quinone), mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001295
Domain description: Dihydroorotate dehydrogenase, conserved site
Occurring in:
  1. Dihydroorotate dehydrogenase (quinone), mitochondrial
IPR005719
Domain description: Dihydroorotate dehydrogenase, class 2
Occurring in:
  1. Dihydroorotate dehydrogenase (quinone), mitochondrial
IPR005720
Domain description: Dihydroorotate dehydrogenase, catalytic
Occurring in:
  1. Dihydroorotate dehydrogenase (quinone), mitochondrial
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Dihydroorotate dehydrogenase (quinone), mitochondrial

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Dihydroorotate dehydrogenase (quinone), mitochondrial
The deposited structure of PDB entry 5mut contains 1 copy of CATH domain 3.20.20.70 (TIM Barrel) in Dihydroorotate dehydrogenase (quinone), mitochondrial. Showing 1 copy in chain A.

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