› 5mue

X-ray diffraction
2.4Å resolution

Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier

Released:
DOI: 10.2210/pdb5mue/pdb
PDB entry 5mue coloured by chain, front view.
PDB entry 5mue coloured by chain, side view.
PDB entry 5mue coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Self-assembled α-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier.
Aeschimann W, Staats S, Kammer S, Olieric N, Jeckelmann JM, Fotiadis D, Netscher T, Rimbach G, Cascella M, Stocker A
Sci Rep 7 4970 (2017)
PMID: 28694484

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155972 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-tocopherol transfer protein Chain: A
Molecule details ›
Chain: A
Length: 228 amino acids
Theoretical weight: 26.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49638 (Residues: 48-275; Coverage: 82%)
Gene names: TPP1, TTPA
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand SO4 1 x SO4
Ligand VIV 1 x VIV
Ligand CL 1 x CL
Ligand ETA 1 x ETA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: I432
Unit cell:
a: 168.184Å b: 168.184Å c: 168.184Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.215
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Vitamin E Biosynthesis and Its Regulation in Plants.
Mène-Saffrané L. (2017)
2 more

1 mention without citation

Self-assembled α-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier.
Aeschimann et al. (2017)