PDBe 5msa

X-ray diffraction
1.2Å resolution

Crystal structure of human carbonic anhydrase isozyme XII with 2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide

Released:
Source organism: Homo sapiens
Entry authors: Smirnov A, Manakova E, Grazulis S

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 12 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 263 amino acids
Theoretical weight: 29.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Best match: O43570 (Residues: 30-291)
Gene name: CA12

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: P21
Unit cell:
a: 77.17Å b: 74.157Å c: 91.559Å
α: 90° β: 108.85° γ: 90°
R-values:
R R work R free
0.144 0.141 0.178
Expression system: Escherichia coli BL21(DE3)